Dr. Casey Means: “The Most Impactful ‘Pill’ in Modern Medicine”

Physionic

Dec 27, 2024

Episode description

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Created with Biorender

0:00 - Introduction
0:28 - The Simple Fix
1:24 - The Most impactful 'Pill' against Mortality
4:10 - The Age Effect
5:03 - Is it *really* walking? / Physiology Explained
7:50 - The Take-Aways

References
[1] Paluch AE, Gabriel KP, Fulton JE, et al. Steps per Day and All-Cause Mortality in Middle-aged Adults in the Coronary Artery Risk Development in Young Adults Study. JAMA Netw Open. 2021;4(9):e2124516. Published 2021 Sep 1. doi:10.1001/jamanetworkopen.2021.24516

[2] Inoue K, Tsugawa Y, Mayeda ER, Ritz B. Association of Daily Step Patterns With Mortality in US Adults [published correction appears in JAMA Netw Open. 2023 Apr 3;6(4):e2311413. doi: 10.1001/jamanetworkopen.2023.11413]. JAMA Netw Open. 2023;6(3):e235174. Published 2023 Mar 1. doi:10.1001/jamanetworkopen.2023.5174

[3] Richter EA. Is GLUT4 translocation the answer to exercise-stimulated muscle glucose uptake?. Am J Physiol Endocrinol Metab. 2021;320(2):E240-E243. doi:10.1152/ajpendo.00503.2020

[4] Kurth-Kraczek EJ, Hirshman MF, Goodyear LJ, Winder WW. 5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. Diabetes. 1999;48(8):1667-1671. doi:10.2337/diabetes.48.8.1667

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:28 - The Simple Fix
1:24 - The Most impactful 'Pill' against Mortality
4:10 - The Age Effect
5:03 - Is it *really* walking? / Physiology Explained
7:50 - The Take-Aways

References
[1] Paluch AE, Gabriel KP, Fulton JE, et al. Steps per Day and All-Cause Mortality in Middle-aged Adults in the Coronary Artery Risk Development in Young Adults Study. JAMA Netw Open. 2021;4(9):e2124516. Published 2021 Sep 1. doi:10.1001/jamanetworkopen.2021.24516

[2] Inoue K, Tsugawa Y, Mayeda ER, Ritz B. Association of Daily Step Patterns With Mortality in US Adults [published correction appears in JAMA Netw Open. 2023 Apr 3;6(4):e2311413. doi: 10.1001/jamanetworkopen.2023.11413]. JAMA Netw Open. 2023;6(3):e235174. Published 2023 Mar 1. doi:10.1001/jamanetworkopen.2023.5174

[3] Richter EA. Is GLUT4 translocation the answer to exercise-stimulated muscle glucose uptake?. Am J Physiol Endocrinol Metab. 2021;320(2):E240-E243. doi:10.1152/ajpendo.00503.2020

[4] Kurth-Kraczek EJ, Hirshman MF, Goodyear LJ, Winder WW. 5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. Diabetes. 1999;48(8):1667-1671. doi:10.2337/diabetes.48.8.1667

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Enhance walks with a weighted vest for better bone health

Using a weighted vest while walking can increase the health benefits, including a specific positive mechanism related to bone health.

Aim for 8,000 steps daily to maximize health benefits

While there is no perfect number, the majority of the health and longevity benefits from walking seem to be captured around 8,000 steps per day.

Utilize muscle contraction from walking to enhance glucose absorption

The benefit of walking isn't about the steps themselves, but the fact that muscle contraction acts as medicine by stimulating cells to absorb glucose from the blood.

Maximize walking benefits for adults over 65

The mortality-reducing benefit of walking is most pronounced for people over the age of 65 compared to younger individuals.

Walk 7,000 steps daily to reduce mortality risk by 70%

A JAMA study found that walking 7,000 steps per day was associated with up to a 70% lower risk of all-cause mortality compared to walking less.

Walk daily for unparalleled health benefits

If walking were a pill, it would be the most impactful pill ever created in modern medicine due to its wide-ranging health benefits.

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