
Drain your Brain, Protect it from Alzheimer’s Disease
Physionic
Dec 15, 2025
Mindsip insights from this episode:
Cool your room to enhance deep sleep and glymphatic drainage
Maintaining a bedroom temperature between 19-21°C (66-70°F) promotes more deep sleep, which drastically improves glymphatic drainage.
Implement four-pillar plan to enhance cognition
A two-year clinical trial improved cognitive function in people aged 60-70 using a plan of specific nutrition, exercise, cognitive training, and vascular risk management.
Prioritize sleep to enhance brain cleaning process
Sleep is likely the biggest factor in maintaining low amyloid plaque levels because it directly supports the glymphatic system's cleaning process.
Understand glymphatic system's selective brain cleaning process
The glymphatic system can clear extracellular proteins like beta-amyloid but cannot wash away intracellular proteins like tau, which is also implicated in Alzheimer's disease.
Improve brain plumbing to reduce dementia risk
Having a dysfunctional perivascular space (PVS) in your brain can increase your risk of dementia by as much as 400%.
Understand brain's glymphatic system for waste removal
The brain's glymphatic system works like a 'pipe within a pipe' around your blood vessels to create a perivascular space that washes away waste.
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