Preventing Aging Mitochondria through Exercise

Physionic

Mar 26, 2025

Episode description

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0:00 - Introduction
0:48 - Exercise's effect on Old Mitochondria
2:07 - Mitochondrial Dynamics
2:39 - Misleading Data...
4:38 - A Lifelong Exercise Effect... Incredible Results...
6:03 - The Electron Transport Chain
8:03 - Energy Generation
9:08 - Caveats..
9:51 - Main Points

References
[Study 425] Konopka AR, Suer MK, Wolff CA, Harber MP. Markers of human skeletal muscle mitochondrial biogenesis and quality control: effects of age and aerobic exercise training. J Gerontol A Biol Sci Med Sci. 2014;69(4):371-378. doi:10.1093/gerona/glt107

Funding/Conflicts: Unknown

[Study 426] Distefano G, Standley RA, Zhang X, et al. Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults. J Cachexia Sarcopenia Muscle. 2018;9(2):279-294. doi:10.1002/jcsm.12272

Funding/Conflicts: Public Funding [National Institutes of Health (NIH) under grants R01AG043120 and P30AG021332, as well as the Translational Research Institute for Metabolism and Diabetes] // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#mitochondrialhealth #mitochondrialdisease

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:48 - Exercise's effect on Old Mitochondria
2:07 - Mitochondrial Dynamics
2:39 - Misleading Data...
4:38 - A Lifelong Exercise Effect... Incredible Results...
6:03 - The Electron Transport Chain
8:03 - Energy Generation
9:08 - Caveats..
9:51 - Main Points

References
[Study 425] Konopka AR, Suer MK, Wolff CA, Harber MP. Markers of human skeletal muscle mitochondrial biogenesis and quality control: effects of age and aerobic exercise training. J Gerontol A Biol Sci Med Sci. 2014;69(4):371-378. doi:10.1093/gerona/glt107

Funding/Conflicts: Unknown

[Study 426] Distefano G, Standley RA, Zhang X, et al. Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults. J Cachexia Sarcopenia Muscle. 2018;9(2):279-294. doi:10.1002/jcsm.12272

Funding/Conflicts: Public Funding [National Institutes of Health (NIH) under grants R01AG043120 and P30AG021332, as well as the Translational Research Institute for Metabolism and Diabetes] // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#mitochondrialhealth #mitochondrialdisease

Mindsip insights from this episode:

Maintain activity to keep muscle physiology youthful

The muscle physiology of active older individuals can be more similar to that of young active individuals than to sedentary people of their own age.

Understand mitochondrial gains across age groups

While exercise improves mitochondrial proteins by a similar relative percentage in young and old, the absolute improvement is smaller in older adults due to a lower starting baseline.

Enhance mitochondrial dynamics through exercise

Exercise increases the proteins responsible for mitochondrial fusion (merging) and fission (splitting) in both young and older individuals.

Maintain cellular energy production through activity

Active individuals, regardless of age, can generate the same amount of cellular energy (ATP) per unit of time from their mitochondria.

Engage in activity to preserve mitochondrial proteins

Active groups, regardless of age, have greater and comparable levels of key mitochondrial proteins relative to sedentary older individuals.

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