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0:00 - Introduction
1:40 - The Anti-Seed Oil Research
5:24 - The Debate Intensifies
8:59 - What does more recent Research say?
14:33 - Omega-6/Omega-3 Ratio
17:55 - Some Critical Information
23:15 - Main Points

References
[Study 467] Ramsden CE, Hibbeln JR, Majchrzak SF, Davis JM. n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. Br J Nutr. 2010;104(11):1586-1600. doi:10.1017/S0007114510004010
Funding/Conflicts: Public Funding [NIAAA and NIH] / No direct Conflicts of Interest

[Study 468] Harris WS, Brouwer IA, Mozaffarian D. n-6 Fatty acids and risk for CHD: consider all the evidence. ​ Br J Nutr. ​ 2011;106(6):951-952. doi:10.1017/S000711451100105X.

Funding/Conflicts: No Funding / Potential direct Conflicts of Interest [Dr. William S. Harris has served as a speaker for GlaxoSmithKline and a consultant for several companies involved in omega-3 fatty acid research and products - truncated]

[Study 469] Ramsden CE, Hibbeln JR, Majchrzak-Hong SF, Davis JM. Don’t disregard the essential distinction between PUFA species. Br J Nutr. 2011;106(7):953-957. doi:10.1017/S0007114511001061

Funding/Conflicts: Public Funding [NIAAA and NIH] / No direct Conflicts of Interest

[Study 470] Hamley S. The effect of replacing saturated fat with mostly n–6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials. Nutr J. 2017;16(1):30. doi:10.1186/s12937-017-0254-5

Funding/Conflicts: None

[Study 471] Hooper L, Martin N, Abdelhamid A, Davey Smith G. Reduction in saturated fat intake for cardiovascular disease. Cochrane Database Syst Rev. 2015;(6):CD011737. doi:10.1002/14651858.CD011737.pub2

Funding/Conflicts: Public Funding [NIH and CLAHRC] / No direct Conflicts of Interest

[Study 472] Wu JHY, Lemaitre RN, Imamura F, et al. Omega-6 fatty acid biomarkers and incident cardiovascular disease and death: an individual-level pooled analysis of 30 prospective cohort studies. Lancet Diabetes Endocrinol. 2014;2(10):856-865. doi:10.1016/S2213-8587(14)70126-2

Funding/Conflicts: Mixed Funding [Non-Profit: Bill & Melinda Gates Foundation; Public: NIH] / No direct Conflicts of Interest

[Study 473] Zhou H, Urpi-Sarda M, Tuladhar AM, et al. Plasma omega-6/omega-3 ratio and mortality: insights from 117,546 UK Biobank participants. eLife. 2022;11:e81751. doi:10.7554/eLife.81751

Funding/Conflicts: Public [National Natural Science Foundation of China] / No direct Conflicts of Interest

[Study 474] Yang WS, Chen YY, Chen PC, et al. Association between Plasma N-6 Polyunsaturated Fatty Acids Levels and the Risk of Cardiovascular Disease in a Community-based Cohort Study. Sci Rep. 2019;9:19298. doi:10.1038/s41598-019-55686-7

Funding/Conflicts: Internal Funding [Department of Internal Medicine at National Taiwan University Hospital] / No direct Conflicts of Interest

[Study 475] Woodhill JM, Palmer AJ, Leelarthaepin B, McGilchrist C, Blacket RB. Low fat, low cholesterol diet in secondary prevention of coronary heart disease. In: Kritchevsky D, ed. Drugs, Lipid Metabolism, and Atherosclerosis. New York, NY: Plenum Press; 1978:317-330.

Funding/Conflicts: Internal Funding [Department of Medicine, University of New South Wales, at Prince Henry Hospital, Little Bay, Australia] // No direct Conflicts of Interest

[Study 476] Ramsden CE, Zamora D, Leelarthaepin B, et al. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ. 2013;346:e8707. doi:10.1136/bmj.e8707.

Funding/Conflicts: Public Funding [Intramural Research Program of the National Institutes of Health (NIH), National Institute on Alcohol Abuse and Alcoholism (NIAAA); National Institute on Aging (NIA)] / No direct Conflicts of Interest

[Study 477] Burr ML, Fehily AM, Rogers S, Welsby E, King S, Sandham S. Diet and reinfarction trial (DART): design, recruitment, and compliance. Eur Heart J. 1989;10(6):558-567.

Funding/Conflicts: Mixed Funding [Welsh Scheme for the Development of Health and Social Research, the Welsh Heart Foundation, and the Health Promotion Research Trust] // No direct Conflicts of Interest