Taking high-dose antioxidant supplements like Vitamin C can blunt the beneficial cellular stress from exercise, leading to fewer improvements in fitness and strength.

A large Cochrane analysis of almost 300,000 participants suggests that vitamin E supplements may actually increase mortality.

At higher supplement doses, Vitamin A is also associated with increased mortality and can weaken bones, damage the liver, and cause birth defects.

The initial study showing resveratrol extended yeast lifespan was a mistake, as the effect only occurred when combined with a specific chemical dye used in the experiment.

Clinical evidence suggests both resveratrol and metformin can reduce testosterone levels, which is a concern as lower levels are associated with higher mortality risks in older men.

Evidence suggests metformin doesn't counter the effects of aging in healthy individuals but instead helps prevent early death from diseases like diabetes.

Both resveratrol and metformin have been shown to reduce the positive effects of exercise, including improvements in blood pressure, cholesterol, and cardiovascular fitness.

Using CRISPR technology, researchers found resveratrol doesn't directly activate SIRT1 but instead stresses the cell by interfering with DNA copying during cell division.