The Confusion surrounding Glycine’s Longevity Effect

Physionic

Oct 23, 2024

Episode description

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References
[Study 297] Miller RA, Harrison DE, Astle CM, et al. Glycine supplementation extends lifespan of male and female mice. Aging Cell. 2019;18(3):e12953. doi:10.1111/acel.12953

Public Funding: National Institute of Aging, One author is affiliated with a glycine selling company (Natural Food Science LLC)

[Study 348] Johnson AA, Cuellar TL. Glycine and aging: Evidence and mechanisms. Ageing Res Rev. 2023;87:101922. doi:10.1016/j.arr.2023.101922

Industry Funding: Tally Health / Potential Conflicts of Interest - All researchers are employees of research

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#glycine #longevityscience

Episode description

Mindsip insights from this episode:

Clarify glycine's paradox for better longevity understanding

Glycine presents a paradox because one of its mechanisms is linked to worse longevity while another is linked to improved longevity, creating confusion about how it works.

#longevity

Boost glutathione production with glycine for cellular protection

Glycine plays an important role in producing the body's master antioxidant, glutathione, which protects cells from damage.

#glutathione

#supplement

Utilize glycine to promote cellular cleanup through autophagy

When glycine is used to eliminate methionine, it is converted into a molecule called sarcosine, which is believed to induce autophagy or cellular cleanup.

#autophagy

#cells

Balance glycine intake to modulate MTOR activity

Although glycine can slightly activate MTOR in isolation, its potent effect of reducing methionine concentration results in a net reduction of overall MTOR activity.

#metabolism

#mTOR

Reduce aging protein activity with glycine

Glycine reduces the activity of the aging-related protein MTOR by removing the molecules that activate it, specifically the amino acid methionine and its derivative SAM.