The Confusion surrounding Glycine’s Longevity Effect
Physionic
Oct 23, 2024
Episode description
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References
[Study 297] Miller RA, Harrison DE, Astle CM, et al. Glycine supplementation extends lifespan of male and female mice. Aging Cell. 2019;18(3):e12953. doi:10.1111/acel.12953
Public Funding: National Institute of Aging, One author is affiliated with a glycine selling company (Natural Food Science LLC)
[Study 348] Johnson AA, Cuellar TL. Glycine and aging: Evidence and mechanisms. Ageing Res Rev. 2023;87:101922. doi:10.1016/j.arr.2023.101922
Industry Funding: Tally Health / Potential Conflicts of Interest - All researchers are employees of research
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#glycine #longevityscience
Mindsip insights from this episode:
Clarify glycine's paradox for better longevity understanding
Glycine presents a paradox because one of its mechanisms is linked to worse longevity while another is linked to improved longevity, creating confusion about how it works.
Boost glutathione production with glycine for cellular protection
Glycine plays an important role in producing the body's master antioxidant, glutathione, which protects cells from damage.
Utilize glycine to promote cellular cleanup through autophagy
When glycine is used to eliminate methionine, it is converted into a molecule called sarcosine, which is believed to induce autophagy or cellular cleanup.
Balance glycine intake to modulate MTOR activity
Although glycine can slightly activate MTOR in isolation, its potent effect of reducing methionine concentration results in a net reduction of overall MTOR activity.
Reduce aging protein activity with glycine
Glycine reduces the activity of the aging-related protein MTOR by removing the molecules that activate it, specifically the amino acid methionine and its derivative SAM.
Supplement glycine to potentially extend lifespan by 5%
In an influential study on model organisms, glycine supplementation extended lifespan by an average of about 5%.
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