Vitamin D and Omega-3 linked to Slower Aging - New Trial!

Physionic

Feb 10, 2025

Episode description

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0:00 - Introduction
1:50 - Omega-3, Vitamin D, Exercise on Aging
3:27 - Why certain results may be disappointing...
5:28 - How much slower do people age?
6:48 - Take-Aways/Dosing

References
[Study 395] Bischoff-Ferrari HA, Gängler S, Wieczorek M, et al. Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial. Nat Aging. Published online February 3, 2025. doi:10.1038/s43587-024-00793-y

Funding/Conflicts: Mixed Funding [Seventh Research Framework Program of the European Commission; University of Zurich; DSM Nutritional Products, Roche Diagnostics, NESTEC, Pfizer, and Streuli Pharma // Potential Conflicts of Interest [Lead researcher has received grants and non-financial support from NESTEC, Pfizer Consumer Healthcare, and Streuli Pharma, as well as non-financial support from DSM Nutritional Products and Roche Diagnostics]

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#agingprevention #agingprocess #aging

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

Next Fish Oil Video: https://youtu.be/tX7xzzIhQgw?si=ju23CSP5sikItm-B

0:00 - Introduction
1:50 - Omega-3, Vitamin D, Exercise on Aging
3:27 - Why certain results may be disappointing...
5:28 - How much slower do people age?
6:48 - Take-Aways/Dosing

References
[Study 395] Bischoff-Ferrari HA, Gängler S, Wieczorek M, et al. Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial. Nat Aging. Published online February 3, 2025. doi:10.1038/s43587-024-00793-y

Funding/Conflicts: Mixed Funding [Seventh Research Framework Program of the European Commission; University of Zurich; DSM Nutritional Products, Roche Diagnostics, NESTEC, Pfizer, and Streuli Pharma // Potential Conflicts of Interest [Lead researcher has received grants and non-financial support from NESTEC, Pfizer Consumer Healthcare, and Streuli Pharma, as well as non-financial support from DSM Nutritional Products and Roche Diagnostics]

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#agingprevention #agingprocess #aging

Mindsip insights from this episode:

Reevaluate exercise impact on epigenetic aging measures

Surprisingly, the exercise routine implemented in the study also had no effect on its own on the measures of epigenetic aging.

Prioritize omega-3s to slow aging process

Omega-3 consumption was the main driver for slowing the pace of aging, even making vitamin D and exercise appear effective when they were combined.

Maximize omega-3 benefits by starting with low baseline levels

The age-slowing benefit of omega-3s was only observed in participants who started with lower blood levels of omega-3s.

Evaluate diet for omega-3 levels before blood testing

You may not need a blood test to know if you'll benefit; if you don't eat fatty fish twice a week or already supplement, you likely have lower levels.

Implement one gram of omega-3s daily to slow aging

The study demonstrated a robust age-slowing effect using a simple intervention of one gram of Omega-3s per day.

Achieve modest biological age reduction with targeted interventions

The best-case scenario from the interventions resulted in a biological age that was about 3.8 months younger after three years of treatment.

Reevaluate vitamin D supplementation for epigenetic aging

In a recent study, vitamin D supplementation alone had no effect on slowing epigenetic aging across four different biological age tests.

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