10-Minute Weekly Update
Dave Asprey
Sep 26, 2025
Episode description
Upgrade your week in just 10 minutes with D(AI)ve Asprey’s essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. Each story includes trusted source links—so you can check the facts.
This episode covers:
- Rapamycin’s Reality Check:
A sweeping new review (September 24) finds that the promise of rapamycin for longevity in healthy adults is still weak and inconsistent. Dave shares why lifestyle levers (fasting, protein timing, smart training) come first, and any rapamycin experiment should be clinician-guided and tracked with labs.
Source: Aging-US press release – September 24, 2025 and EurekAlert science brief – September 24, 2025
- Senolytics Get Precise:
New research (September 23) shows that not all “zombie cells” (senescent cells) are equal in how they respond to anti-aging drugs—so future protocols will be timed and typed, not one-size-fits-all.
Source: Aging-US research stream – September 23, 2025
- AI Healthcare: Promise and Pause:
The latest market outlook (September 23) says AI in healthcare is surging toward a $100B+ market by 2030, but 70% of doctors still want humans in the loop for diagnosis. Dave shares how to use AI as your copilot—not your captain.
Source: Crescendo.ai – September 23, 2025
- Medical Policy Meets Machine Logic:
A new federal pilot now lets AI approve or deny Medicare coverage, possibly cutting off therapies before a human review happens. Dave explains how to demand explainability, fair appeals, and human override to protect access.
Source: KFF Health News policy rundown – September 25, 2025
- Longevity Headlines You Can Use:
Forest bathing wins renewed praise for helping with blood pressure and stress.
Northwestern’s SuperAger project links strong social ties to resilient brain health.
Human trials now test an antibody therapy to regrow lost teeth.
Source: XandroLab Longevity Roundup – Week of Sept 22–25, 20
Mindsip insights from this episode:
Improve sleep quality with Kill Switch hot cocoa supplement
The Kill Switch supplement is a hot cocoa drink with GABA, magnesium glycinate, and tart cherry extract designed to improve sleep without causing grogginess.
Track deep sleep, REM minutes, and resting heart rate for brain health
To improve brain health, focus on tracking and improving three specific metrics: deep sleep minutes, REM minutes, and your morning resting heart rate.
Protect sleep and journal to lock in psilocybin gains
The 10-14 days after a psilocybin session are a critical window to 'lock in the gains' by protecting sleep, journaling, and keeping digital noise low.
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