10-Minute Weekly Update

Dave Asprey

Sep 26, 2025

Episode description

Upgrade your week in just 10 minutes with D(AI)ve Asprey’s essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. Each story includes trusted source links—so you can check the facts.

This episode covers:

- Rapamycin’s Reality Check:

A sweeping new review (September 24) finds that the promise of rapamycin for longevity in healthy adults is still weak and inconsistent. Dave shares why lifestyle levers (fasting, protein timing, smart training) come first, and any rapamycin experiment should be clinician-guided and tracked with labs.

Source: Aging-US press release – September 24, 2025 and EurekAlert science brief – September 24, 2025

- Senolytics Get Precise:

New research (September 23) shows that not all “zombie cells” (senescent cells) are equal in how they respond to anti-aging drugs—so future protocols will be timed and typed, not one-size-fits-all.

Source: Aging-US research stream – September 23, 2025

- AI Healthcare: Promise and Pause:

The latest market outlook (September 23) says AI in healthcare is surging toward a $100B+ market by 2030, but 70% of doctors still want humans in the loop for diagnosis. Dave shares how to use AI as your copilot—not your captain.

Source: Crescendo.ai – September 23, 2025

- Medical Policy Meets Machine Logic:

A new federal pilot now lets AI approve or deny Medicare coverage, possibly cutting off therapies before a human review happens. Dave explains how to demand explainability, fair appeals, and human override to protect access.

Source: KFF Health News policy rundown – September 25, 2025

- Longevity Headlines You Can Use:

Forest bathing wins renewed praise for helping with blood pressure and stress.
Northwestern’s SuperAger project links strong social ties to resilient brain health.
Human trials now test an antibody therapy to regrow lost teeth.

Source: XandroLab Longevity Roundup – Week of Sept 22–25, 20

Episode description

This episode covers:

- Rapamycin’s Reality Check:

Source: Aging-US press release – September 24, 2025 and EurekAlert science brief – September 24, 2025

- Senolytics Get Precise:

Source: Aging-US research stream – September 23, 2025

- AI Healthcare: Promise and Pause:

Source: Crescendo.ai – September 23, 2025

- Medical Policy Meets Machine Logic:

Source: KFF Health News policy rundown – September 25, 2025

- Longevity Headlines You Can Use:

Forest bathing wins renewed praise for helping with blood pressure and stress.
Northwestern’s SuperAger project links strong social ties to resilient brain health.
Human trials now test an antibody therapy to regrow lost teeth.

Source: XandroLab Longevity Roundup – Week of Sept 22–25, 20

Mindsip insights from this episode:

Improve sleep quality with Kill Switch hot cocoa supplement

The Kill Switch supplement is a hot cocoa drink with GABA, magnesium glycinate, and tart cherry extract designed to improve sleep without causing grogginess.

#sleep

#supplement

Match senolytics to specific cell subtypes for effective treatment

Senescent cells are a diverse "zoo," and effective treatment requires matching the senolytic to the specific cell subtype and its cycle status.

#aging

#regeneration

Implement intermittent "hit and run" senolytic dosing to minimize cell stress

Use intermittent "hit and run" dosing for senolytics rather than a daily drip to reduce collateral stress on healthy cells.

#longevity

Challenge AI algorithms to ensure Medicare coverage access

A new federal pilot program could allow algorithms to approve or deny Medicare coverage, acting as an opaque "financial bouncer at the clinic door.".

#AI

#healthcare

Regrow natural teeth with antibody therapy

Human trials are underway for an antibody therapy that could make age-related tooth loss a reversible condition by regrowing natural teeth.

#regeneration

#therapy

Foster community and enhance mitochondria for superaging

Research on "superagers" points to a combination of social engagement and distinct brain architecture, or "mitochondria plus community," as protective against aging.

#community

#mitochondria

Utilize Lima laser for at-home cellular skin repair

The Lima laser is a clinic-grade cold laser for at-home use that triggers skin repair at the cellular level, not just the surface.

#laser

#skin

Prioritize lifestyle changes over rapamycin for longevity benefits

Despite animal studies, clinical evidence for rapamycin's lifespan benefits in healthy humans is lacking, and lifestyle levers like fasting hit the same pathway with fewer unknowns.

#longevity

#rapamycin

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