Biohacking Your Heart Health: The Life-Saving Molecule You NEED to Know | Dr. Anurag Singh
Dave Asprey
May 6, 2025
Mindsip insights from this episode:
Reverse mitochondrial fragmentation to rejuvenate cellular age
Young, healthy mitochondria are rod-shaped and networked, while aged mitochondria become fragmented and circular, a change that can be reversed.
Avoid high-dose creatine to prevent sleep disruption
Taking very high doses of creatine can increase ATP so much that it reduces your sleep drive, causing you to wake up fully alert in the middle of the night.
Recognize ovaries as energy powerhouses for fertility
Cells in female ovaries contain 100,000 mitochondria each, far more than neurons, highlighting their immense energy needs for fertility.
Prioritize carbohydrates over protein to spike mTOR for muscle growth
Contrary to popular belief, carbohydrates are more effective than protein at spiking mTOR after a workout, which is a key pathway for muscle building.
Stop taking supplements to evaluate their effectiveness
For supplements you don't immediately feel, the true test of their effectiveness is to stop taking them and notice if your health or energy declines.
Take Mitopure at fast's start to boost autophagy
For maximum benefit, it is hypothesized you should take Mitopure at the beginning of a fast to enhance the body's natural mitochondrial cleanup process, autophagy.
Utilize Mitopure to modulate immunity and restore T-cell function
Unlike the longevity drug rapamycin which can be an immunosuppressant, Mitopure (Urolithin A) acts as an immune modulator that can help restore T-cell function.
Boost mitochondrial biogenesis with exercise and Mitopure stack
A powerful stack to boost PGC-1α for mitochondrial biogenesis includes exercise, Mitopure, NAD precursors, and a low dose of oral nicotine (1-3mg).
Distinguish between harmful and beneficial ceramides for heart health and skincare
The long-chain ceramides that signal heart damage are different from the beneficial, plant-based ceramides used in skincare products.
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