Biohacking Your Heart Health: The Life-Saving Molecule You NEED to Know | Dr. Anurag Singh
Dave Asprey
May 6, 2025
Episode description
What if you could reverse the age of your heart...without leaving home?
In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You’ll discover how mitochondrial decline drives heart failure, why postmenopausal women face skyrocketing cardiac risks, and how one powerful molecule, Urolithin A, can rejuvenate your heart’s energy systems.
Dr. Singh shares clinical research showing how Urolithin A improves mitochondrial function, boosts endurance, and may even reverse biological aging markers in the heart. You’ll also learn how simple lifestyle biohacks, combined with cellular nutrition, can protect your cardiovascular health and extend your healthspan.
What You’ll Learn in This Episode:
• The link between mitochondrial decline and heart failure
• Why women’s cardiac risk skyrockets after menopause
• How Urolithin A stimulates mitophagy and energy renewal
• New human clinical data on reversing cardiac aging markers
• Biohacking strategies to fortify your cardiovascular health
• How to optimize endurance, recovery, and heart resilience
THANK YOU TO OUR SPONSORS!
-STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order.
-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Timeline Website – https://www.timeline.com/partners/dave-asprey
• Timeline Instagram - https://www.instagram.com/timeline_longevity/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https:/
Mindsip insights from this episode:
Reverse mitochondrial fragmentation to rejuvenate cellular age
Young, healthy mitochondria are rod-shaped and networked, while aged mitochondria become fragmented and circular, a change that can be reversed.
Avoid high-dose creatine to prevent sleep disruption
Taking very high doses of creatine can increase ATP so much that it reduces your sleep drive, causing you to wake up fully alert in the middle of the night.
Recognize ovaries as energy powerhouses for fertility
Cells in female ovaries contain 100,000 mitochondria each, far more than neurons, highlighting their immense energy needs for fertility.
Prioritize carbohydrates over protein to spike mTOR for muscle growth
Contrary to popular belief, carbohydrates are more effective than protein at spiking mTOR after a workout, which is a key pathway for muscle building.
Stop taking supplements to evaluate their effectiveness
For supplements you don't immediately feel, the true test of their effectiveness is to stop taking them and notice if your health or energy declines.
Take Mitopure at fast's start to boost autophagy
For maximum benefit, it is hypothesized you should take Mitopure at the beginning of a fast to enhance the body's natural mitochondrial cleanup process, autophagy.
Utilize Mitopure to modulate immunity and restore T-cell function
Unlike the longevity drug rapamycin which can be an immunosuppressant, Mitopure (Urolithin A) acts as an immune modulator that can help restore T-cell function.
Boost mitochondrial biogenesis with exercise and Mitopure stack
A powerful stack to boost PGC-1α for mitochondrial biogenesis includes exercise, Mitopure, NAD precursors, and a low dose of oral nicotine (1-3mg).
Distinguish between harmful and beneficial ceramides for heart health and skincare
The long-chain ceramides that signal heart damage are different from the beneficial, plant-based ceramides used in skincare products.
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