Does Glycine extend Lifespan? [Study 297 Study Analysis]
Physionic
Jun 12, 2024
Mindsip insights from this episode:
Recognize sex-specific lifespan gains from glycine
The median lifespan increase from glycine was more pronounced in male mice at 6.2% compared to female mice at 3.7%.
Utilize glycine supplementation to extend lifespan
In a large, multi-lab study, glycine supplementation was shown to significantly extend the lifespan of mice, indicated by a rightward shift in the survival curve.
Leverage robust mouse study findings for reliable insights
The study's findings are particularly strong because it used genetically diverse mice and was replicated independently across three different labs simultaneously.
Utilize glycine to stabilize immune cells and reduce inflammation
Glycine may reduce chronic inflammation by binding to chloride channels on immune cells, making them more stable and less likely to become pro-inflammatory.
Incorporate glycine to inhibit mTOR pathway and promote longevity
Glycine may promote longevity by binding with the amino acid methionine, preventing it from activating the mTOR pathway which is linked to aging and cell growth.
Investigate variability in longevity benefits across research labs
The longevity benefits were not uniform across all three testing sites, with the University of Texas lab reporting the most robust effects.
Investigate glycine's impact on lifespan in oldest male mice
Glycine extended the lifespan of the oldest 10% of male mice by 4.5%, but this benefit was not statistically significant in the oldest female mice.
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