Half of Us are Deficient in this Mineral… and its Shrinking our Brain

Physionic

Aug 4, 2025

Episode description

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0:00 - Introduction
0:35 - The Effect on our Brain
4:30 - Brain Size and Quality
5:27 - Dementia Risk
12:05 - How should we think about all this? Main Points.

References
[Study 497] Alateeq K, Walsh EI, Cherbuin N. Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences. Eur J Nutr. 2023;62(5):2039–2051. doi:10.1007/s00394-023-03123-x.

Funding/Conflicts: Non-Profit [Council of Australian University Librarians] // No direct Conflicts of Interest

[Study 498] Patel V, Akimbekov NS, Grant WB, Dean C, Fang X, Razzaque MS. Neuroprotective effects of magnesium: implications for neuroinflammation and cognitive decline. Front Endocrinol (Lausanne). 2024;15:1406455. doi:10.3389/fendo.2024.1406455

Funding/Conflicts: No Funding // Potential direct Conflicts of Interest [The author(s) declared that they were an editorial board member of Frontiers]

[Study 499] Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 2010;65(2):165-177. doi:10.1016/j.neuron.2009.12.026.

Funding/Conflicts: Public Funding [NIH (National Institutes of Health); National Natural Science Foundation of China (NSFC)] // Potential Conflicts of Interest [Guosong Liu, explicitly declares that he is a co-founder of Magceutics]

[Study 500] Chen F, Wang J, Cheng Y, et al. Magnesium and cognitive health in adults: a systematic review and meta-analysis. Adv Nutr. 2024;15:100272. doi:10.1016/j.advnut.2024.100272.

Funding/Conflicts: Public [NIH and USDA] // No direct Conflicts of Interest

[Study 501] Alam AB, Thomas DS, Lutsey PL, Shrestha S, Alonso A. Associations of Serum Magnesium with Brain Morphology and Subclinical Cerebrovascular Disease: The Atherosclerosis Risk in Communities-Neurocognitive Study. Nutrients. 2021;13(12):4496. Published 2021 Dec 16. doi:10.3390/nu13124496

Funding/Conflicts: Public Funding [U.S. National Institutes of Health] // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#magnesium #brainhealth

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:35 - The Effect on our Brain
4:30 - Brain Size and Quality
5:27 - Dementia Risk
12:05 - How should we think about all this? Main Points.

References
[Study 497] Alateeq K, Walsh EI, Cherbuin N. Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences. Eur J Nutr. 2023;62(5):2039–2051. doi:10.1007/s00394-023-03123-x.

Funding/Conflicts: Non-Profit [Council of Australian University Librarians] // No direct Conflicts of Interest

[Study 498] Patel V, Akimbekov NS, Grant WB, Dean C, Fang X, Razzaque MS. Neuroprotective effects of magnesium: implications for neuroinflammation and cognitive decline. Front Endocrinol (Lausanne). 2024;15:1406455. doi:10.3389/fendo.2024.1406455

Funding/Conflicts: No Funding // Potential direct Conflicts of Interest [The author(s) declared that they were an editorial board member of Frontiers]

[Study 499] Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 2010;65(2):165-177. doi:10.1016/j.neuron.2009.12.026.

Funding/Conflicts: Public Funding [NIH (National Institutes of Health); National Natural Science Foundation of China (NSFC)] // Potential Conflicts of Interest [Guosong Liu, explicitly declares that he is a co-founder of Magceutics]

[Study 500] Chen F, Wang J, Cheng Y, et al. Magnesium and cognitive health in adults: a systematic review and meta-analysis. Adv Nutr. 2024;15:100272. doi:10.1016/j.advnut.2024.100272.

Funding/Conflicts: Public [NIH and USDA] // No direct Conflicts of Interest

[Study 501] Alam AB, Thomas DS, Lutsey PL, Shrestha S, Alonso A. Associations of Serum Magnesium with Brain Morphology and Subclinical Cerebrovascular Disease: The Atherosclerosis Risk in Communities-Neurocognitive Study. Nutrients. 2021;13(12):4496. Published 2021 Dec 16. doi:10.3390/nu13124496

Funding/Conflicts: Public Funding [U.S. National Institutes of Health] // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#magnesium #brainhealth

Mindsip insights from this episode:

Recognize complexities in single nutrient studies

It is difficult to isolate the true effect of a single nutrient like magnesium because its impact is often overshadowed by major factors like exercise, body weight, and overall calorie intake.

Aim for 400mg of magnesium daily for optimal brain health

Until better evidence is available, aiming for the recommended daily allowance of around 400mg for men and 320mg for women is a safe bet for brain health.

Question the significance of magnesium intake on brain size

A study linking higher magnesium intake to a larger brain size based some of its key associations on only 1-3% of the total participants, questioning the real-world significance.

Ensure daily magnesium intake exceeds 240mg for brain health

Consuming less than 240mg of magnesium per day is repeatedly associated with poor brain health outcomes.

Critique low-quality magnesium trials on cognition

The few randomized control trials on magnesium and cognition are considered low quality due to high risk of bias and being conducted on small groups with serious health complications.

Balance magnesium intake to reduce dementia risk

A non-linear analysis of studies found a U-shaped relationship where both very low and very high levels of magnesium intake were associated with dementia.

Supplement magnesium to enhance brain connections

In animal models, magnesium supplementation was shown to increase the density of axon terminals, which are the connections between brain neurons.

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