
Half of Us are Deficient in this Mineral… and its Shrinking our Brain
Physionic
Aug 4, 2025
Mindsip insights from this episode:
Recognize complexities in single nutrient studies
It is difficult to isolate the true effect of a single nutrient like magnesium because its impact is often overshadowed by major factors like exercise, body weight, and overall calorie intake.
Aim for 400mg of magnesium daily for optimal brain health
Until better evidence is available, aiming for the recommended daily allowance of around 400mg for men and 320mg for women is a safe bet for brain health.
Question the significance of magnesium intake on brain size
A study linking higher magnesium intake to a larger brain size based some of its key associations on only 1-3% of the total participants, questioning the real-world significance.
Ensure daily magnesium intake exceeds 240mg for brain health
Consuming less than 240mg of magnesium per day is repeatedly associated with poor brain health outcomes.
Critique low-quality magnesium trials on cognition
The few randomized control trials on magnesium and cognition are considered low quality due to high risk of bias and being conducted on small groups with serious health complications.
Balance magnesium intake to reduce dementia risk
A non-linear analysis of studies found a U-shaped relationship where both very low and very high levels of magnesium intake were associated with dementia.
Supplement magnesium to enhance brain connections
In animal models, magnesium supplementation was shown to increase the density of axon terminals, which are the connections between brain neurons.
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