The Multiple Mechanisms Fish Oil affects your Heart

Physionic

Nov 13, 2024

Episode description

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References
[Study 353] Liu QK. Triglyceride-lowering and anti-inflammatory mechanisms of omega-3 polyunsaturated fatty acids for atherosclerotic cardiovascular risk reduction. J Clin Lipidol. 2021;15(4):556-568. doi:10.1016/j.jacl.2021.05.007

Unknowing Funding: No Known Conflicts of Interest

[Study 354] Mason RP, Libby P, Bhatt DL. Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid. Arterioscler Thromb Vasc Biol. 2020;40(5):1135-1147. doi:10.1161/ATVBAHA.119.313286

Public/Non-Profit Funding: National Heart, Lung, and Blood Institute, American Heart Association, and RRM Charitable Fund // Potential Conflicts of Interest: Some researchers are advisors for Industry (Cardax, Cereno Scientific, and others)

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#omega3benefits #omega3

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

References
[Study 353] Liu QK. Triglyceride-lowering and anti-inflammatory mechanisms of omega-3 polyunsaturated fatty acids for atherosclerotic cardiovascular risk reduction. J Clin Lipidol. 2021;15(4):556-568. doi:10.1016/j.jacl.2021.05.007

Unknowing Funding: No Known Conflicts of Interest

[Study 354] Mason RP, Libby P, Bhatt DL. Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid. Arterioscler Thromb Vasc Biol. 2020;40(5):1135-1147. doi:10.1161/ATVBAHA.119.313286

Public/Non-Profit Funding: National Heart, Lung, and Blood Institute, American Heart Association, and RRM Charitable Fund // Potential Conflicts of Interest: Some researchers are advisors for Industry (Cardax, Cereno Scientific, and others)

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#omega3benefits #omega3

Mindsip insights from this episode:

Block fat-producing genes with omega-3s

Omega-3s can enter the cell's nucleus and competitively bind to DNA, thereby blocking proteins that would normally activate genes for triglyceride synthesis.

Activate GPR120 with omega-3s to reduce inflammation

Omega-3s bind to and activate a specific cellular receptor called GPR120, which inhibits the production of inflammatory molecules that can cause insulin resistance.

Reduce cellular fats to combat insulin resistance

An accumulation of specific fat molecules called DAGs and ceramides inside your cells can directly inhibit the insulin signaling pathway, causing insulin resistance.

Destroy fat-production instructions with omega-3s

Omega-3s can destabilize the messenger RNA (mRNA) from fat-producing genes, causing it to be destroyed before it can be used to create triglyceride-forming enzymes.

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