The Silent Fire Behind Chronic Disease—and How to Put It Out

Mark Hyman

Sep 8, 2025

Episode description

Inflammation is the body’s natural way of healing, but when it becomes chronic and hidden, it quietly drives many of today’s most common health problems—heart disease, diabetes, dementia, cancer, autoimmune conditions, and more. Unlike the redness and swelling from a cut or sprain, this “silent inflammation” often goes unnoticed while slowly damaging tissues and speeding up aging. Modern life fuels the fire: processed foods, food additives, pollution, plastics, chronic stress, too much sitting, and poor sleep. The good news is inflammation can be calmed by simple daily choices—eating colorful whole foods like berries, leafy greens, beans, nuts, seeds, and omega-3 rich fish; adding herbs and spices like turmeric and cumin; moving regularly; practicing relaxation; and repairing gut health. Even small shifts, like climbing stairs, eating within a shorter window, or reducing sugar, can make a big difference. By lowering inflammation, the body finds balance again, opening the door to more energy, resilience, and healthy aging.

In this episode, I discuss, along with Dr. Shilpa Ravella and Dr. David Furman, why it’s important to be aware of systemic inflammation and how to address it.

Dr. Ravella is a gastroenterologist and Assistant Professor of Medicine at Columbia University Medical Center. She is the author of A Silent Fire: The Story of Inflammation, Diet & Disease, which investigates inflammation—the hidden force at the heart of modern disease. Her writing has appeared in The Atlantic, New York Magazine, The Wall Street Journal, TIME, Slate, Discover, and USA Today, among other publications. 

Dr. David Furman is Associate Professor and Director of the Bioinformatics Core at the Buck Institute for Research on Aging, as well as the Director of the Stanford 1000 Immunomes Project. He obtained his doctoral degree in immunology from the School of Medicine, University of Buenos Aires, Argentina, for his work on cancer immune-surveillance. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans. He has published nearly thirty scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others. 

This episode is brought to you by BIOptimizers.

Head to bioptimizers.com/hyman and use code HYMAN to save 15%.

Full-length episodes can be found here:
What Causes Inflammation And How Can You Treat It?

The Silent Killer: Inflammation And Chronic Disease

How Silent Inflammation Accelerates Aging

Episode description

Inflammation is the body’s natural way of healing, but when it becomes chronic and hidden, it quietly drives many of today’s most common health problems—heart disease, diabetes, dementia, cancer, autoimmune conditions, and more. Unlike the redness and swelling from a cut or sprain, this “silent inflammation” often goes unnoticed while slowly damaging tissues and speeding up aging. Modern life fuels the fire: processed foods, food additives, pollution, plastics, chronic stress, too much sitting, and poor sleep. The good news is inflammation can be calmed by simple daily choices—eating colorful whole foods like berries, leafy greens, beans, nuts, seeds, and omega-3 rich fish; adding herbs and spices like turmeric and cumin; moving regularly; practicing relaxation; and repairing gut health. Even small shifts, like climbing stairs, eating within a shorter window, or reducing sugar, can make a big difference. By lowering inflammation, the body finds balance again, opening the door to more energy, resilience, and healthy aging.

In this episode, I discuss, along with Dr. Shilpa Ravella and Dr. David Furman, why it’s important to be aware of systemic inflammation and how to address it.

Dr. Ravella is a gastroenterologist and Assistant Professor of Medicine at Columbia University Medical Center. She is the author of A Silent Fire: The Story of Inflammation, Diet & Disease, which investigates inflammation—the hidden force at the heart of modern disease. Her writing has appeared in The Atlantic, New York Magazine, The Wall Street Journal, TIME, Slate, Discover, and USA Today, among other publications. 

Dr. David Furman is Associate Professor and Director of the Bioinformatics Core at the Buck Institute for Research on Aging, as well as the Director of the Stanford 1000 Immunomes Project. He obtained his doctoral degree in immunology from the School of Medicine, University of Buenos Aires, Argentina, for his work on cancer immune-surveillance. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans. He has published nearly thirty scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others. 

This episode is brought to you by BIOptimizers.

Head to bioptimizers.com/hyman and use code HYMAN to save 15%.

Full-length episodes can be found here:
What Causes Inflammation And How Can You Treat It?

The Silent Killer: Inflammation And Chronic Disease

How Silent Inflammation Accelerates Aging

Mindsip insights from this episode:

Utilize ancestral plants like scallions to combat inflammation

Ancestral versions of plants, like scallions instead of onions, are much more powerful from an inflammation-damping standpoint.

Identify CXCL9 as a crucial aging marker

The chemokine CXCL9, largely produced by the lining of your blood vessels, has been identified as one of the most important contributors to inflammatory age.

Eliminate harmful food additives to protect gut health

Food additives like carboxymethyl cellulose and polysorbate 80 can wipe out your microbiome and cause inflammation by thinning the protective mucus layer in your gut.

Incorporate seaweed for unique anti-inflammatory fibers

You can find anti-inflammatory fibers in seaweed that you don't find in terrestrial (land) plants.

Prioritize exposome to combat chronic disease

95% of chronic disease is caused by the exposome (your total life exposures), not your genes.

Reduce inflammatory immune cells through exercise, regardless of weight loss

Exercise can decrease the amount of inflammatory immune cells infiltrating your fat tissue, even in the absence of weight loss.

Utilize iAge test to assess immunity and predict disease risk

A new test developed at Stanford called iAge (immune age) can analyze your immune system to track inflammation and predict disease risk.

Evaluate inflammation levels to assess cholesterol risk

If your cholesterol is high but your inflammation is not, you are not at great risk for heart disease.

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