The Silent Fire Behind Chronic Disease—and How to Put It Out
Mark Hyman
Sep 8, 2025
Mindsip insights from this episode:
Utilize ancestral plants like scallions to combat inflammation
Ancestral versions of plants, like scallions instead of onions, are much more powerful from an inflammation-damping standpoint.
Identify CXCL9 as a crucial aging marker
The chemokine CXCL9, largely produced by the lining of your blood vessels, has been identified as one of the most important contributors to inflammatory age.
Eliminate harmful food additives to protect gut health
Food additives like carboxymethyl cellulose and polysorbate 80 can wipe out your microbiome and cause inflammation by thinning the protective mucus layer in your gut.
Incorporate seaweed for unique anti-inflammatory fibers
You can find anti-inflammatory fibers in seaweed that you don't find in terrestrial (land) plants.
Prioritize exposome to combat chronic disease
95% of chronic disease is caused by the exposome (your total life exposures), not your genes.
Reduce inflammatory immune cells through exercise, regardless of weight loss
Exercise can decrease the amount of inflammatory immune cells infiltrating your fat tissue, even in the absence of weight loss.
Utilize iAge test to assess immunity and predict disease risk
A new test developed at Stanford called iAge (immune age) can analyze your immune system to track inflammation and predict disease risk.
Evaluate inflammation levels to assess cholesterol risk
If your cholesterol is high but your inflammation is not, you are not at great risk for heart disease.
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