#1 Aging Expert: Dementia, Diabetes & Heart Disease Start After 40 When You Ignore This

Rangan Chatterjee

Jun 17, 2026

Episode description

The Thrive Tour: Transform Your Health and Happiness, a live show: Book Your Tickets https://drchatterjee.com/live

This episode is brought to you by:
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You might assume that how you’ll age is down to your genes. That your disease risk is out of your hands, sealed by midlife, and something to manage rather than change. But Dr Florence Comite has spent 30 years proving that assumption wrong. And for this conversation, she’s brought the evidence.

Florence is a clinician-scientist, Yale and National Institutes of Health-trained endocrinologist, and some might call her a disruptor. Her life’s work has been built on the radical idea that decline is not inevitable, it is detectable. And because it’s detectable, it’s reversible. Her new book, Invincible: Defy Your Genetic Destiny to Live Better Longer, has the core message that our health trajectory is far from fixed. By tuning into our body’s signals, and understanding our physiology, we can make targeted changes to improve how we feel, function and age.

In this episode, Florence and I explore why the Western medical model – built around treating disease not creating health – leaves people in the dark when it comes to disease risk. We discuss why the type and frequency of blood tests your doctor currently offers is lacking, as well as what you should ask for (or seek privately) if you want to truly understand your health.

Florence talks us through the five blood biomarkers she believes every adult should know about, including one – fasting insulin – that your doctor is highly unlikely to check but that I agree with her is absolutely critical. And she explains why free testosterone is vital for both men and women, how it connects to muscle, memory, bone density, blood sugar and heart health, and why optimising it has transformed some of her patients’ lives.

We also sing the praises of continuous glucose monitors. We discuss what they reveal about your individual response to food, why two people can eat the same meal with different results, and how the order in which you eat your meal can change your health.

This is a conversation about taking control. It’s about owning your data, your trends – and your future. Florence and I share the belief that our healthcare systems need to move from reactive to proactive. In time, I’m hopeful that will happen. But in the meantime her clinic – and my own Do Health app – are paving an exciting way for you to get ahead of the curve.

#feelbetterlivemore

Find out more about Dr Comite:
Website https://florencecomite.com/
Instagram https://www.instagram.com/drflorencecomite
Tik Tok https://www.tiktok.com/@drflorencecomite
X https://www.x.com/florencecomite
YouTube https://www.youtube.com/@drflorencecomitemd

Dr Comite’s book:
Invincible: Defy Your Genetic Destiny to Live Better, Longer UK https://amzn.to/4eoXqi9 US https://amzn.to/4edlhTn

#feelbetterlivemore #feelbetterlivemorepodcast
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DISCLAIMER: The content in the podcast and on this webpage is not intended to constitute or be a substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.

Mindsip insights from this episode:

Maintain HbA1c under 5.0 to reduce chronic disease risk

An optimal HbA1c level is under 5.0, as your risk of chronic disease increases with each tenth of a point above this.

#chronic-disease

#glucose

Transform health management into a virtual experience

Health management will become like mobile banking, where individuals can access their own data and receive personalized, virtual guidance to create their own health.

#AI

#personalized-health

Optimize testosterone levels to combat age-related muscle loss

Declining testosterone is the main factor in age-related muscle loss, and optimizing it is crucial for both men and women starting in their 30s.

#muscle

#testosterone

Utilize HCG to stimulate natural testosterone production

For men, using HCG (human chorionic gonadotropin) is a preferred method as it stimulates the body to produce its own testosterone rather than replacing it directly.

#supplement

#testosterone

Understand weight gain risks from birth control pills due to testosterone reduction

Birth control pills can cause weight gain in young women because they reduce testosterone, which is essential for maintaining muscle and metabolic health.

#birth-control

#testosterone

Track five key biomarkers for optimal health

The five most important biomarkers to track for health are fasting sugar, HbA1c, fasting insulin, cholesterol risk ratio, and free testosterone.

#blood-test

#testing

Aging limits lifestyle's impact on optimizing testosterone levels

While a poor lifestyle can lower testosterone, you cannot use lifestyle changes like diet and exercise to raise it to optimal levels as you age.

#aging

#testosterone

Utilize continuous glucose monitor to understand unique food responses

Your individual glucose response to foods like bananas versus cookies is unique, which is why using a continuous glucose monitor (CGM) is so valuable.