Rethinking Cholesterol, Keto, and Cardiovascular Risk with Nick Norowitz

Mark Hyman

Apr 30, 2025

Episode description

Who in the world would try to lower their cholesterol by eating an entire sleeve of Oreos every day for a month? Meet Nick Norwitz, PhD, an Oxford graduate and Harvard medical student who did just that—in an effort to test a hypothesis about cholesterol and metabolic health.

After reversing a serious inflammatory condition with a ketogenic diet, Nick saw his LDL cholesterol spike. Instead of panicking, he turned to research—and self-experimentation—to better understand what those numbers really meant.

In this episode of The Dr. Hyman Show, we explore:

• The health crisis that led Nick to a ketogenic diet

• Why his LDL cholesterol jumped—and what questions it raised

• The Oreo experiment and what it did (and didn’t) reveal

• The nuance around LDL, metabolic health, and cardiovascular risk

• What the science—and Nick’s own experience—suggests about meat, veganism, and finding a diet that works

Check out the episode to hear this fascinating conversation. 

View Show Notes From This EpisodeGet Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcastSign Up for Dr. Hyman’s Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast


Episode description

Who in the world would try to lower their cholesterol by eating an entire sleeve of Oreos every day for a month? Meet Nick Norwitz, PhD, an Oxford graduate and Harvard medical student who did just that—in an effort to test a hypothesis about cholesterol and metabolic health.

After reversing a serious inflammatory condition with a ketogenic diet, Nick saw his LDL cholesterol spike. Instead of panicking, he turned to research—and self-experimentation—to better understand what those numbers really meant.

In this episode of The Dr. Hyman Show, we explore:

• The health crisis that led Nick to a ketogenic diet

• Why his LDL cholesterol jumped—and what questions it raised

• The Oreo experiment and what it did (and didn’t) reveal

• The nuance around LDL, metabolic health, and cardiovascular risk

• What the science—and Nick’s own experience—suggests about meat, veganism, and finding a diet that works

Check out the episode to hear this fascinating conversation. 

View Show Notes From This EpisodeGet Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcastSign Up for Dr. Hyman’s Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast


Mindsip insights from this episode:

Test health markers for clearer disease risk assessment

Measuring important health markers like insulin, triglycerides, HDL, and more—not just LDL cholesterol—gives a much clearer picture of your health and disease risk. Many doctors don’t routinely test for these, but you can now order comprehensive lab tests yourself to get real data and track your progress.

Challenge cholesterol with context: Oreos and keto experiment reveals impact

In a self-experiment, eating a sleeve of Oreo cookies daily alongside a keto diet lowered LDL cholesterol by 71% in just 16 days—more than double the effect of a high-dose statin drug. This was done as a dramatic experiment to show how adding carbs can powerfully impact cholesterol, especially for lean people on keto. The message isn’t that Oreos are healthy, but that context and individual responses really matter.

Leverage data-driven health tools for personalized choices

With new tools and lab tests, everyone can access and understand their own health data. This empowers you to make smarter choices, personalize your health journey, and be less dependent on “one size fits all” advice.

Enhance metabolic health to boost mental and physical well-being

Poor metabolic health doesn’t just lead to diabetes or heart disease—it’s also connected to mental health issues like depression, anxiety, and even conditions like autism and Alzheimer’s. Improving your diet and metabolism can have wide-ranging benefits.

Choose quality supplements to fill nutrition gaps

It's often hard to get all the nutrients you need from food alone, especially omega-3 fats, so quality supplements can help support heart, brain, and immune health. Always choose well-sourced, minimally processed products for best results.

Stay curious and experiment thoughtfully for health improvement

The best way to improve your health is to stay curious, try different approaches, and track how you feel and what your lab results show. You don’t have to be a scientist—just be willing to experiment thoughtfully and learn from your own data.

Utilize carnivore diet to alleviate severe gut issues

A strict carnivore diet (all animal foods) has helped some people with severe gut conditions like Crohn’s or colitis when nothing else worked. This may be less about the meat and more about removing other foods that irritate the gut, showing the power of elimination diets for certain health problems.

Reassess red meat's role in health amidst lifestyle factors

Large studies blaming red meat for health problems often overlook other lifestyle factors and are not very reliable. For many people, meat can be a healthy, nutrient-dense food, while processed foods high in sugar and starch are much more strongly linked to poor health.

Choose natural sweeteners to protect health from artificial risks

Emerging research suggests artificial sweeteners like aspartame can cause problems such as anxiety that can even be passed to future generations, as well as affecting gut health and possibly raising the risk for heart disease. Choosing natural sweeteners like stevia or monk fruit, or simply drinking water, may be safer.

Monitor body response on low-carb diets for optimal health

People with obesity or diabetes often see improvements in cholesterol and other health markers on a ketogenic or low-carb diet. However, lean individuals doing keto are more likely to experience large increases in LDL cholesterol, so it's important to monitor how your body responds.

Address root causes to prevent chronic conditions

Modern medicine often focuses on treating symptoms of diseases (like heart disease or diabetes) instead of addressing the common root causes, such as poor metabolic health and insulin resistance. Improving metabolic health by focusing on diet, exercise, and lifestyle can help prevent or even reverse many chronic conditions at once.

Experiment with diets to discover what works for your body

People respond very differently to diets like keto, vegan, or carnivore, depending on their body type, genetics, and health status. Some people see big improvements in health markers, while others may have negative effects, such as cholesterol levels shooting up on keto if they're already lean and healthy. Personal experimentation and tracking your own results is key to finding what works for you.

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